Publications


Research Articles

2019

Jeganathan, S., Wendt, M., Kiehstaller, S., Brancaccio, D., Kuepper, A., Pospiech, N., Carotenuto, A., Novellino, E., Hennig, S.*, Grossmann, T. N.* 2019.

Constrained peptides with fine-tuned flexibility inhibits NF-Y transcription factor assembly. Angew. Chem. Int. Ed., 58:2-10.
  [NCBI PubMed Entry] [download file]

Clausen, I., Litty, FA., Hennig, S., Vetter, I. R., Kotthaus, J., Altmann, K. S., Ott, G., Havemeyer, A., Clement, B., Schade, D.* 2019.
Discovery of N-(4-Aminobutyl)-N’-(2-Methoxyethyl)guanidine as the First Selective, Non-Amino Acid, Catalytic Site Inhibitor of hDDAH-1. J. Med. Chem., in revision.
  [NCBI PubMed Entry] [download file]

Hennig, S.*, Neubacher, S.* 2019.
Fluorescent RNA tags: current and future applications. Fut. Med. Chem., 11(19):2483-2485.
  [NCBI PubMed Entry] [download file]

Neubacher, S., Hennig, S., TN Grossmann* 2019.
Organisch-chemisch stabilisierte Enzyme für eine nachhaltige Wirtschaft. BIOspektrum, 25(3):338-339, doi: 10.1007/s12268-019-1039-5.
  [Springer Link] [download file]

Neubacher, S., Hennig, S.* 2019.
RNA Structure and Cellular Applications of Fluorescent Light-Up Aptamers. Angew. Chem. Int. Ed., 131:1278-1291, doi: 10.1002/anie.201806482.
  [NCBI PubMed Entry] [download file]

2018

Pelay-Gimeno, M., Bange, T., Hennig, S., Grossmann, T., N..* 2018.
In Situ Cyclization of Native Proteins: Structure-Based Design of a Bicyclic Enzyme. Angew. Chem. Int. Ed., 57(35):11164-11170, doi: 10.1002/anie.201804506.
  [NCBI PubMed Entry] [download file]

Pospiech, N., Cibis, H., Dietrich, L., Müller, F., Bange, T., Hennig, S.* 2018.
Identification of novel PANDAR protein interaction partners involved in splicing regulation. Sci. Rep., 8(1):2798, doi: 10.1038/s41598-018-21105-6.

  [NCBI PubMed Entry] [download file]

2017

Roszyk, L., Kollenda, S., Hennig, S.* 2017.
Using a specific RNA-protein interaction to quench the fluorescent RNA Spinach. ACS Chem. Biol., 12(12):2958-2964.
  [NCBI PubMed Entry] [download file]

Krüger, D.M., Glas, A., Bier, D., Pospiech, N., Wallraven, K., Dietrich, L., Ottmann, C., Koch, O.*, Hennig, S.*, Grossmann, T.N.* 2017.
Structure-Based Design of Non-Natural Macrocyclic Peptides that Inhibit Protein-Protein Interactions. J. Med. Chem., 60:8982-8988 doi: 10.1021/acs.jmedchem.7b01221.

  [NCBI PubMed Entry] [download file]

2015

Hennig, S., Kong, G., Mannen, T., Sadowska, A., Kobelke, S., Blythe, A., Knott, G.J., Iyer, K.S., Ho, D., Newcombe, E.A., Hosoki, K., Goshima, N., Kawaguchi, T., Hatters, D., Trinkle-Mulcahy, L., Hirose, T., Bond, C.S., Fox, A.H. 2015.
Prion-like domains in RNA binding proteins are essential for building subnuclear paraspeckles. J. Cell Biol., 210(4):529-539
  [NCBI PubMed Entry] [download file]

Lee, C.U., Hahne, G., Hanske, J., Bange, T., Bier, D., Rademacher, C., Hennig, S., Grossmann, T.N. 2015.
Redox Modulation of PTEN Phosphatase Activity by Hydrogen Peroxide and Bisperoxidovanadium Complexes. Angew. Chem. Int. Ed., 54(46):13796-13800
  [NCBI PubMed Entry] [download file]

2014

Chakravarty, D., Sboner, A., Nair, S., S., Giannopoulou, E., Li, R., Hennig, S., Mosquera, J., M., Pauwels, J., Park, K., Kossai, M., MacDonald, T., Y., Fontugne, J., Erho, N., Vergara, I., A., Ghadessi, M., Davicioni, E., Jenkins, R., B., Palanisamy, N., Chen, Z., Nakagawa, S., Hirose, T., Bander, N., H., Beltran, H., Fox, A., H., Elemento, O., Rubin, M., A. 2014.
The oestrogen receptor alpha-regulated lncRNA NEAT1 is a critical modulator of prostate cancer. Nature Comm., 5(5383):1-16

  [NCBI PubMed Entry] [download file]

Milroy, L., Grossmann, T. N., Hennig, S., Brunsveld, L. and Ottmann, C. 2014.
Modulators of Protein−Protein Interactions. Chem. Rev., 114(9):4695-748

   [NCBI PubMed Entry] [download file]

2013

Thiel, P., Röglin, L., Meissner, N., Hennig, S.,* Kohlbacher, O.* and Ottmann, C.* 2013.
Virtual screening and experimental validation reveal novel small-molecule inhibitors of 14-3-3 protein–protein interactions. Chem. Comm., 49(76):8468-70

  [NCBI PubMed Entry] [download file]

 

2012

Kucera, N., Schmalen, I., Hennig, S., Strauss, H., Grudziecki, A., Wieczorek, C., Kramer, A. and Wolf, E. 2012. Unwinding the Differences of the Mammalian PERIOD Proteins from Crystal Structure to Cellular Function. PNAS, 109(9):3311-3316

  [NCBI PubMed Entry] [download file]

2011

Lee, M., Passon, D. M., Hennig, S., Fox, A. H. and Bond, C., S. 2011. Construct optimization for studying protein complexes: obtaining diffraction-quality crystals of the pseudosymmetric PSPC1–NONO heterodimer. Acta Cryst. D, D67: 981–987

  [NCBI PubMed Entry] [download file]

2010

Rose, R., Erdmann, S., Bovens, S., Wolf, A., Rose, S., Hennig, S., Waldmann, H. and Ottmann, C. 2010. Identification and Structure of Small-Molecule Stabilizer of 14-3-3 Protein-Protein Interactions. Angew. Chem. Int. Ed., 49(24): 4129-4132

  [NCBI PubMed Entry] [download file]

2009

Hennig, S.,  Strauss, H., Vanselow, K., Yildiz, Ö., Schulze, S., Arens, J., Kramer, A. and Wolf, E. 2009. Structural and Functional Analyses of PAS Domain Interactions of the Clock Proteins Drosophila PERIOD and Mouse PERIOD2. PLoS Biology, 7(4): e94

  [NCBI PubMed Entry] [download file]

2007

Schöning, J. C., Streitner, C., Page, D. R., Hennig, S., Uchida, K., Wolf, E., Furuay, M. and Staiger, D. 2007. Autoegulation of the circadian slave oscillator component AtGRP7 and regulation of its targets is impaired by a single RNA recognition motif point mutation.  Plant J., 52(6):1119–1130.

  [NCBI PubMed Entry] [download file]

Berndt, A., Kottke, T., Breitkreuz, H., Dvorsky, R., Hennig, S., Alexander, M. and Wolf, E. 2007. A Novel Photoreaction Mechanism for the Circadian Blue Light Photoreceptor Drosophila Cryptochrome. J. Biol. Chem., 282(17):13011–13021.

  [NCBI PubMed Entry] [download file]

2005

Yildiz, Ö., Doi, M., Yujnovsky, I., Cardone, L., Berndt, A., Hennig, S., Schulze, S., Urbanke, C., Sassone–Corsi, P. and Wolf, E. 2005. Crystal Structure and Interactions of the PAS Repeat Region of the Drosophila Clock Protein PERIOD. Mol. Cell, 17(1):69–82.

  [NCBI PubMed Entry] [download file]