Solid Phase Peptide Synthesis


  To modify an protein-protein or protein-nucleic acid complex we use Fmoc based solide phase peptide synthesis (SPSS) to generate binding molecules. We either modulate them during synthesis or introduce post-synthetic modifications to optimize our molecules of interest. Subsequent biophysical, thermodynamical and structural analysis gives us an detailed understanding of the binding mechanism which is then used for another round of chemical synthesis.

 

  We use these techniques on projects like NF-Y or SMAD.