NF-Y Transcriptional Regulation


Figure 1: Crystal structure of the NF-Y heterotrimer. The NF-YB/C heterodimer (licght and dark grey) forms a histone-fold that can interact with the double stranded DNA (black/orange), but still needs NF-YA (blue) to be locked into place.
Figure 1: Crystal structure of the NF-Y heterotrimer. The NF-YB/C heterodimer (licght and dark grey) forms a histone-fold that can interact with the double stranded DNA (black/orange), but still needs NF-YA (blue) to be locked into place.

  The Nuclear Factor Y (NF-Y) is a hetero trimeric transcription factor that consists of the sub-units A, B and C. The later pre-form a heterodimer that scans the double stranded DNA via its histone fold structure, whereas binding to the sub-unit A (blue in figure 1) locks the trimer into place on CCAAT DNA elements.

  These DNA promoter regulate various target genes involved in e.g. apoptosis or cancer metabolics. Therefore, we are interested in modulating the transcriptional outcome of this protein-DNA complex.