SMAD Signaling


  The TGF-beta- (Transforming Growth Factor) as well as the homologous BMP- (Bone Morphogenic Protein) signaling pathways are regulating and maintaining a certain proportion of the cellular transcription by the interaction of the SMAD (Small and Mothers Against Decaplentaplegic) family of adaptor proteins with their targets. SMADs are modifying the activity of transcription factors, their repressors and activators by direct protein-protein interaction. We are identifying additional new SMAD binding partners by MS and mutagenic studies. Structural investigations as well as biochemical analysis are the basis on how we try to understand these new signalling cross-talks.